Supercritical CO2 extraction (SCFE) is a safe method of efficient botanical material with a solvent that is “tunable” in a system that optimizes oil quality, speed. CO2 Extraction: Your Complete Guide To CO2 Cannabis Oil Well, have we got a treat for you: supercritical CO2 extraction! This removes the danger of explosions from the CO2 extraction process as well as potentially. Learn how CO2 cannabis extracts are produced and familiarize yourself with the itself to be one of the leading technologies for industrial hash oil production. Supercritical fluid extraction (SFE) is the process of separating components from .
Oil Supercritical Extraction Process CO2 Cannabis
Using butane as the extraction solvent creates what is known as butane hash oil. To do this, the process starts with cannabis and liquid butane in a pressurized and heated system. By using evaporation under a vacuum, it is then possible to remove the butane solvent. The vacuum turns the butane from liquid to a vapor, making it easier to remove. This kind of extract is also known as shatter, which is a clear material that typically includes THC, CBD and other chemical components, including terpenes.
To really make shatter, which is a hard version of butane hash oil, terpene content must be kept low or it works like a solvent that makes the extract soft. The right starting sample can help to reduce the terpenes present in the final product, such as by starting with cured flowers. On the other hand, the butane hash oil can be heated to remove terpenes after extraction as they are more volatile than cannabinoids like THC and CBD.
Cannabis alcohol extraction Several common forms of cannabis extraction rely on a solvent, such as alcohol. In brief, the cannabis soaks in alcohol, usually ethanol, the plant material is then removed, the liquid filtered, and the alcohol is removed with some form of evaporation. One of the biggest challenges is the inherent polarity of solvents like ethanol—meaning it has a propensity to mix with water and dissolve water-soluble molecules like chlorophyll.
Removing the chlorophyll from the extract is important as it produces an undesirable, bitter flavor. A cannabis tincture created using alcohol-based extraction. This method can be performed at atmospheric pressure, but the temperature is carefully controlled, especially during evaporation. This process can also take time and must be done carefully to avoid danger as ethanol is highly inflammable.
One of the biggest benefits of this form of extraction is that there is no risk of leaving toxic residual chemicals in the final cannabis extract and, it enables the co-extraction of all compounds of interest, chiefly cannabinoids and terpenoids. The Ethos-4 closed-loop ethanol extractor. Capna Fabrication YouTube Channel.
Cannabis CO 2 extract being dispensed from a supercritical CO 2 system following extraction. A selection of supercritical CO 2 extraction equipment available from Eden Labs. With the cannabis components extracted, the supercritical CO 2 goes into a condenser and turns into a liquid that can be filtered and used again.
Consequently, very little reagent is used. That makes this method economical to run and reduces the need to dispose of waste. Butane extract on the tip of a paperclip. Coaster on Wikimedia Commons. In particular DE 41 00 A1 describes the manufacture of 6,dihydrohydroxy-cannabidiol, which is obtained by reacting olivetol and cis-p-menthene-1,8-diol, and its further reaction to trans-O9-tetrahydrocannabinol by using suitable catalysts. A drawback of this prior-art process, however, is the relatively high expenditure and the ultimately costly product obtained.
Eine Expertise zu pharmakologischen and psychosozialen Konsequenzen, Stuttgart: As of February 1, , dronabinol may be prescribed as an anaesthetic in Germany. WO A1 moreover relates to the extraction of hemp for the isolation of tetrahydrocannabinol from the natural cannabis plant.
What is described in particular is an extraction process with an apolar organic solvent, followed by fractional distillation under reduced pressure in order to produce 3 5 distillates having high tetrahydrocannabinol contents.
As suitable apolar solvents, lower alkanes such as, e. In accordance with Examples 1, 2, 3, 4 and 7 of reference 7 A1, exclusively drug hemp having tetrahydrocannabinol dry concentrations of 2. Starting out from the above explained prior art and from the new legal situation in the Federal Republic of Germany, it accordingly was the object of the present invention to provide D9-tetrahydrocannabinol, D8-tetrahydro-cannabinol and cannabidiol in pure form and as an extract in the form of preparations for medical applications, wherein the active principles should preferably be obtained from hemp varieties having low cannabinoid contents for the reason of better availability.
The production of C02 extracts is known in principle. Owing to currently valid legislation, industrial hemp species of the fiber type may contain 0. It is thus advantageous if cannabis plant material of the fiber type may be used for the production of primary extracts containing THC and CBD, for it is possible to employ such starting material having a low O9-THC content for the inventive process without any further operating and handling permissions as are required in the case of drug hemp types.
Varieties entering into consideration here are in particular the French varieties Fedora 19, Felina 45 and Futura 77, the Hungarian varieties Kompolti and Uniko-B and the Finnish variety Finola , for the average for all varieties lies clearly below the specified limits Mediavilla, V. When it is possible to employ drug hemp types, however, the O9-THC content in the primary extract is higher than in one produced of fiber hemp.
In the subcricital range, in contrast, a temperature of approx. As an alternative, the C02 laden with THC and CBD as well as with 3 o proportions of reduced mono- and sesquiterpenes, flavonoids, chlorophylls and alkaloids may also be passed over adsorbers charged with adsorbents or separators Figure 1. Preferred adsorbents are those selected from the group comprised of: The inventive primary extracts from Cannabis plant material containing o9-THC and cannabidiol are substantially free from monoterpenes and sesquiterpenes and moreover free from alkaloids and flavonoids, and contain practically no chlorophylls.
Where, however, a hemp of the fiber type is used as a starting material, which is being preferred, CBD and in a given case the carboxylic acids thereof are found as the main constituents of the primary extract. The primary extract of the invention contains at least reduced proportions of monoterpene and sesquiterpene hydrocarbons, alkaloids, 2 o flavonoids and chlorophylls, and is preferably already free from these components, in particular from alkaloids, flavonoids and chlorophylls.
Where undesirable waxes are present in certain industrial and drug hemp varieties, these are purified after completed primary extraction and decarboxylation by subsequent dissolution of the primary extract, e. In order tc obtain the purified extract, the solvent, e. Here a THC may form depending on process conditions, which in itself also possesses interesting pharmacological properties.
Thus THC may, for example, be employed as an antiemetic in pediatric oncology. Cyclization takes place under the following conditions: The obtained extract is separated out under pressure and temperature conditions subcricital for C02, preferably at approx. As a water-binding agent zeolitic molecular sieves having a pore size of 3 - 10 A, preferably 5 A may be used, and useful catalysts are metal-containing halogen salts containing the metals tin, zinc, iron or titanium, 2 o preferably zinc chloride.
To this end, preferably a high-pressure column Figure 3 subdivided into segments, comprising a bottom segment for dissolving the primary extract 3 o in supercritical C02, a purification segment filled, e. As cannabidiol taken for itself has interesting pharmacological prorperties while furthermore lacking the psychotropic hallucinogenic effect of O9-THC, cannabidiol itself is also of interest for practical application because it may be used, e.
Further advantages and features of the present invention result from the description of practical examples and from the drawings, wherein: COZ having been brought to a temperature of approx. At the upper end of extracting vessel 4, an extract enriched in the cannabinoids leaves the vessel via conduit 6 a and arrives at the bottom of separating vessel 5a.
The separating vessels 5a and 5b are in the exemplary case filled with various zeolitic molecular sieves and with diatomaceous earth as an adsorbent. In separating vessels 5a and 5b, the same pressure and temperature conditions prevail as in extracting vessels 1 - 4. The zeolitic molecular sieves placed in container 6a have an internal surface of approx.
This C02 extraction mixture thus purified exits from the head of vessel 5b via conduit 7, pressure regulation valve 8, with extraction pressure being reduced to less than 75 bar, in the exemplary case to approx. The extract mixture consisting of C02 and essentially of THC and cannabidiol as well as the carboxylic acids thereof, exits from separating vessel 10 via conduit 11, 2s pressure regulation valve 12, heat exchanger 13, and finally is conveyed into separating vessel With the aid of pressure regulation valve 12, the separation pressure in container 14 is set to pressure conditions subcricital for C02, in the exemplary 3 o case 50 bar.
Under these conditions the pure C02 is separated from the primary extract enriched in THC and cannabidiol and the carboxylic acids thereof in separating vessel The pure C02 is conveyed via conduit 15 to liquefier 17 that is equipped with a condenser coil From here the liquid C02 is supplied via pressurizing pump 18 to heat exchanger 19, to be available for the following extraction cycle.
For opening the extracting vessel, i. A mixture of decarboxylated primary extract, water-binding agent and catalyst is introduced into the extracting vessel From there the liquid C02 is supplied via pressurizing pump to heat exchanger , to be available for the following extraction cycle.
It is here that the CBD is obtained. Via valve the obtained D9-THC may be withdrawn. From here the liquid C02 is supplied via pressurizing pump to heat exchanger , to be available for the following extraction cycle. Modifications in the described plant systems are very well possible without the scope of the invention being restricted thereby. As industrial hemp of the fiber type, in the present exemplary case the 3 o French Cannabis sativa variety Fedora 19 is employed. The raw drug has an average content of approx.
As a result, a primary extract having the properties indicated in Table 1 is obtained. An industrial hemp having the following raw drug data: To to this end, g of air-dried, pulverized industrial hemp was extracted for hours in 4 I of hexane in accordance with the Soxhlet method.
The solvent was removed under reduced pressure, and the obtained extract was analyzed with a view to the parameters indicated in Table 1.
Moreover in comparison with the COZ primary extract of the present invention, there results a disadvantageously high chlorophyll content of 3. For the extract of the invention, the chlorophyll content thus is lower by a factor of almost than in the prior-art extracts. Moroeover what is conspicuous in comparison with the extract of the invention are the highly elevated more than fold flavonoid glycoside contents of the ethanol and hexane extracts.
The contents of undesirable monoterpenes listed in Table 1 are higher by a factor of than in the two primary extracts obtained with ethanol and 3 5 hexane than in the C02 primary extract, and while the sesquiterpene content is higher by a factor 20 to 40 than in the inventive C02 extracts.
It is moreover noted that the primary extracts obtained with the aid of lipophilic solvents contain the alkaloids that are readily soluble in these solvents, such as, e. In contrast, already the primary extracts of the invention without any further purification steps - as shown in Table 1 - practically do not contain any mroe cannabisativin.
Table 2 shows the components of a secondary extract after completed 3 5 anellation. Table 2 Secondary extract following cyclization Fig. Table 3 to Purified primary extract after chemical purification in a high-pressure column Fig. Se arator Se arator No.
The Best Cannabis Extraction Methods for Marijuana Concentrates
The extraction agent in the supercritical CO2 extraction process is carbon dioxide pure CBD oil, special cleaning techniques are crucial; the supercritical CO2. Expertly engineered and built, Apeks Supercritical CO2 cannabis oil feature simple fractional extraction and cold separation processes to preserve volatile oils. Cannabis CO2 extract being dispensed from a supercritical CO2 system as the extraction solvent creates what is known as butane hash oil.