With the news that even the World Health Organization and the United Nations might be de-criminalizing cannabidiol (CBD) in , we. Scientists have identified over 80 cannabinoids while studying the compounds found in Cannabis sativa. Tetrahydrocannabinol, THC, and. After decades in which only high-THC cannabis was available in North America and beyond, CBD-rich strains and products are now available to medical users.
Although CBD does perform multiple actions in the body, its best-known function in the ECS is its potential to inhibit the activity of the enzyme called fatty acid amide hydrolase FAAH. Importantly, however, whereas THC can have negative effects, such as feelings of anxiety, mild hallucinations, dizziness, rapid heart rate, slowed reaction times, and food cravings, the anandamide made in the body appears to exert positive effects on mood, memory, brain function, and pain.
Because CBD is relatively safe, lacks the negative side effects of THC, and can be readily derived from hemp rather than marijuana, the natural products industry has been flooded with products labeled as CBD. But well before this recent phenomenon, a British pharmaceutical company began studying the merits of CBD as an alternative to the drugs being used to treat resistant childhood epilepsy.
The ECS is not just a bodily system that just does one thing — far from it, in fact. ECS receptors are widely distributed throughout the body.
But what about the rest of the ECS? And in addition to anandamide, humans also make an endocannabinoid called 2-archidonoyl glycerol 2-AG , which is degraded by the enzyme monoacylglycerol lipase MAGL. If our goal is to support and nourish the entire ECS, then focusing on a single molecule like CBD that only works on one part of the ECS might not be the best approach.
Hemp contains dozens of active molecules, including a range of phytocannabinoids. The phytocannabinoid beta-caryophyllene BCP , which is found in plants such as black pepper and clove, binds to the CB2 receptor, which supports the functions of 2AG. Other natural plant compounds, particularly certain terpenoids, have actions that are complementary to the phytocannabinoids.
Jacqueline is a Naturopathic Doctor with almost 20 years expertise in medical nutrition. While she briefly had a private practice, she has spent most of her career in the dietary supplement industry as a formulator, speaker, writer, and educator.
Get free shipping on all orders. Shop now Discount and free shipping only available to retail customers. Contiguous United States only. Done correctly, however, pharmacies can ensure a profitable business model while keeping patients safe from dangerous or low-quality CBD products.
Beyond choosing a CBD product that provides revenue, care must be given to its quality. When Selma Alami, PharmD, co-owner and pharmacy manager of Mustang Drug in Mustang, Oklahoma was choosing a product to sell in her pharmacy, she focused on picking a product that was of the highest quality, from how the product looked on the shelf to its absorbent technology. I wanted it to be exclusive and high-end in terms of quality. Alami paid special attention to the bioavailability of the product she chose and looked for independent potency and purity testing proof.
Some of these products still remain at the top of search engine lists and are promoted by bloggers, and while an FDA Warning Letter does not always mean the product is inferior, the letters could give you clues for products and marketing terminology to be wary of when picking out a brand. Federally, OTC CBD oil is considered a schedule I medication, but with many states having recreational and medicinal allowances, the shade of grey concerning what is allowable continues to darken—and depending on the state, the amount of THC allowed in products varies.
Owners can minimize risk by consulting an attorney who specializes in business or pharmacy law. Questions that are more ethical in nature and not necessarily clinical might arise from patients. For the full article, please visit www. Williams, PharmD, contributing writer.
Beyond CBD – Supporting the Entire Endocannabinoid System
The miraculous benefits of hemp are all the rage these days! With this huge surge in popularity for CBD and all it has to offer, it seems that. Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation ? Annual Review of Neuroscience. Vol. (Volume publication date July. It should be noted that this discussion goes well beyond CBD only, as new products containing additional cannabinoids like CBG, THCV, and.