Study Reviews Evidence Supporting Use of Cannabinoids to Treat ALS novel and more effective therapeutic options for ALS patients are still needed. whereas the few clinical trials that investigated cannabinoids-based medicines of ALS-related symptoms, not on the control of disease progression.”. ALS (also known as Lou Gehrig's Disease) is a fatal motor neuron disease, By Stacey Marie Kerr MD, Hawaiian Ethos Medical Director both factors, though specific studies on ALS and cannabis have yet to be done. Cannabis may relieve symptoms of ALS. Read the latest scientific research into medicinal cannabis and it's potential uses treating ALS.
for Cannabis – Medicinal Lou needed ALS – Gehrig’s trials Clinical Disease
Although ALS is clinically a heterogeneous disease, the first sign of ALS is often weakness in one leg, one hand, the face, or the tongue. The weakness slowly spreads to both arms and both legs. Over time, problems with speaking, eating, walking, and breathing increase. Weight loss is nearly ubiquitous in ALS and has a negative, statistically significant impact on survival [ 2 ].
The most common causes of death are pneumonia, lung- or heart failure. Because of the variability in the speed of the progression, median survival varies widely between days [ 3 ] and 67 to 71 months [ 4 , 5 ]. As ALSphenotypes differ, each person's disease course is likely unique.
Some of these cases seem to be associated with mutations in the gene for an enzyme called copper-zinc superoxide dismutase 1 Cu-Zn SOD1 which destroys reactive oxygen species ROS , but a dozen or more of other genetic mutations may also be linked to ALS. Among the primary hypotheses underlying motor neuron vulnerability are susceptibility to excitotoxicity and oxidative damage. Oxidative stress, mitochondrial dysfunction and excitotoxicity are thus general hallmarks.
Whereas Riluzole can be administered orally, Edavarone must be given by IV route. Riluzole may increase survival in certain groups by about 3 to 24 months at the best [ 4 ]; no reversal of symptoms has been reported. Complementary and alternative medicine may increase survival [ 2 ]. Given the lack of medications with a more pronounced effect on disease progression and survival, it is not surprising that many patients try complementary or alternative therapies.
About eighteen months ago, the patient, a general practitioner at the beginning of his sixties, observed a painless weakness and impaired function of his right hand. Within about 3 weeks, paresthesia, at the beginning only on the little finger, progressed to the other fingers of the same hand, and included the foot of the same side, with a similar spread from digit 5 to digit 3, suspecting a motor neuron disease.
With a slight delay, dysarthria was also observed. At the time of neurological examination, about three weeks after the first symptoms, the impaired function of the right hand and right foot as well as a slurred speech had progressed. There were no sensory abnormalities. Diagnose was made on clinical aspects only; neuroimaging was not done. No risk factor e. However, condition worsened, with fasciculation, muscle cramps, increased weakness, dysarthria as well as dysphagia.
Six weeks after starting CBD, complete reversal of paresthesia in the foot was observed and most of paresthesia in the right hand; only a slight weakness remained in digit 5 and 4. One of the biggest issues regarding cannabis use is the fact that it is not legal everywhere and it can be hard to obtain or expensive even if it is legal.
There is also a stigma around cannabis, which could limit people with ALS who use cannabis from disclosing their use to their doctor, limiting important health conversations. The side effects to cannabis can also keep people from seeking it out. Cannabis can make some feel detached and others felt they relied too much on its numbing qualities to avoid the reality of their diagnosis. Although there have been several studies testing the effects of cannabis on mice with ALS , there have been no clinical studies on the effect of cannabis on people with ALS.
This is a topic that would benefit from more research and clinical trials, which will be determined as legislation changes over the next several years. As its effects are studied more in-depth, its association, help or detriment with ALS symptoms will become more clear. We believe that the use of medical marijuana in the treatment of amyotrophic lateral sclerosis is a decision that should be made by the person with ALS in consultation with a physician and family.
We believe the decision regarding this treatment option is entirely a matter of individual conscience and should consider potential benefits, harmful effects and legal consequences. We believe alternative medical treatments should be based on results from controlled clinical studies and should be subject to the same standards applicable to other prescription medications and treatments such as quality, safety and efficacy.
You are commenting using your WordPress. You are commenting using your Twitter account. In fact, there are studies today across many different health sectors in which cannabis has helped many with great relief from pain and other complications from a certain illness. It is our hope at ALSNews that researchers continue to look into this more and provide viable treatments and medications that can help people live better quality lives.
FDA need to pay attention. I believe this will help ALS patients and a lot of other medical issues. My husband has als and we want to use the oil to help with his symptoms but we want to be safe.
First off, his appetite and mood has improved, and he has become more interested in life, whereas it appears the disease in him at least can cause minimal movement and interest. If it can alleviate his mood throughout all of this — as he also is bipolar — that would be huge, because he has naturally, found this to be a very depressing experience.
None of that is true with regards to cannabis. The only time it impairs memory is for a few hours if you use way too much. Thank you all for your testimonies as I had a older gentleman and his son in my store today to inquire about CBD and ALS and through your testimonies they now considering CBD as part of their therapeutic regiment. Having ALS is a very depressing thing to have. Walk to the fridge and get out a beer and drink it after sitting down to relax… did you even think about any of the things you just did or did your body just do it automatically?
The human body is awesome until it gets sick. Best put having ALS is like being stuck in Groundhog day over and over again until you die. His condition seemed to be improving after 3 weeks of having this water soluble BioCBDplus. I tried it orally and could not cope with it.
Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease: A Case Report
Also known as Lou Gehrig's disease, ALS is a rapidly progressive Clinical trials show riluzole increases ALS survival by two to three months. and a mitochondrial function-enhancing agent would be required to If you are currently suffering from ALS, see if you qualify for medical marijuana today. Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND ), and Lou Gehrig's disease, is a disease which causes the death of neurons Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials Health Ministry's coordination is not required. (1)Muscular Dystrophy Association/Amyotrophic Lateral Sclerosis Center, University of Washington Medical Center, Seattle, WA, USA. [email protected] processes occur simultaneously in this devastating disease. disease modifying and symptom management viewpoint, clinical trials with cannabis are.